According to José Ferreras Pagán in his book Biografía de las Riquezas de Puerto Rico, Hacienda Destino was established by Juan Capó and then owned by his estate.  In 1902 it consisted of one thousand eight hundred eighty cuerdas of which four hundred fifty were planted with sugarcane producing approximately one thousand three hundred hogsheads of raw sugar annually.  The Juan Capó referred to by Ferreras Pagán was Venezuelan born of Spanish descent Pedro Juan Capó Planchart (1809-1874), one of three sons (Luis Florentino Capó Planchart and Federico Capó Planchart) of Francisco Capó Coll (1776-1841)and Caracas, Venezuela born Theresa de Jesús del Carmen Planchart Rondón (1789- 1869).  Pedro Juan was married to Constanza Ortiz de la Renta (1815-1857) and was Mayor of Ponce from September to December 1856 where he always lived until his death.  Ferreras Pagán states that in 1902 its 1st Overseer was Enrique Mercado and its administrator was Vicente Balbás Capó (1864-1926), grandson of Pedro Juan Capó. Planchart.

Although the date the hacienda was established is unclear, Hacienda Destino was already established by 1844 when on March 21 of that year, a concession for water right was granted to Jose R. Alomar, Pedro J. Capó and N. Márquez to extract water from the Coamo River for irrigation purposes at their haciendas Santa Isabel, Destino and Florida. Between 1846 and 1886,  the owners of haciendas Florida, Santa Isabel, and Destino agreed to finance and build an irrigation system for their three properties.  Funds for the construction came from their own money and some help from the Spanish Crown.  The irrigation system consisted of a set of structures built in brick, stone and lime mortar masonry with concrete plastering to transport water from the Coamo River to the fields of their sugarcane plantations.  Identified as the "Irrigation System of the Three Haciendas", it was registered in the National Register of Historic Places on December 13, 2016.

Upon the death of Pedro Juan Capó Planchart in 1874, the then one thousand seven hundred twenty six acre hacienda was inherited and administered by his daughters Eufemia Capó Ortiz de la Renta (1847-1918) who was married to Francisco Parra Duperón (1827-1899), Matilde Capó Ortiz de la Renta (1835-1902) who was married to Pedro Juan Rosaly Ascencio (1828-1886), Ursula Capó Ortiz de la Renta (1835-1913) who was married to Francisco Arce Romero (1839-1990) and Mercedes Capó Ortiz de la Renta (1838-1894) who was married to Spaniard Casiano Balbás Nieto ( -1889).  The hacienda continued to operate under the name Sucn. Capó until the first few years of the 1900s when Hacienda Destino stopped processing and sent all sugarcane grown on it lands to be processed at the recently established Central Aguirre. 

Hacienda Destino remained in the Capó family until 1920 when it was acquired by Luce & Co., a subsidiary of Central Aguirre.  In 1964 some one thousand twenty acres of land of the former hacienda were sold to farmer Pedro Ramos before the Government of Puerto Rico acquired all other lands through the Land Authority.

The brick and masonry building pictured below, which original structure has been altered, was supposedly the processing plant.  It was located on the North side of PR-1, between Santa Isabel to Salinas about 3 km from the town of Santa Isabel.