Already by 1841, Hacienda Santa Bárbara was owned by Bárbara María Balseiro de la Plaza (1794-1876).  It was located in Barrio Cambalache and consisted of 345 cuerdas.  Bárbara Balseiro was also owner by inheritance of Hacienda Islote in the barrio of the same name near the mouth of the Arecibo River.  

Bárbara was married to Ramón Gandia Silva and had at least twelve children, Felicita, Pedro, Teresa, Ramón, Isabel, Ricardo, Miguel, Carmen, Emilio,  Zenón, Amalia and Maria de la Concepción Gandia Balseiro (1835-1879).  Upon Barbara's death, her daughters Amalia and Maria de la Concepción inherited Hacienda Santa Bárbara as well as Hacienda Islote.

Maria de la Concepción married Manuel de Jesús Zeno Correa (1818-1902) and were the parents of well known doctor, politician and author Manuel Zeno Gandia (1855-1930) who in 1883 married Ana Antongiorgi Franceschi, daughter of Francisco Maria Atongiorgi, who inherited Hacienda Maria in Yauco from his father Juan Maria Antongiorgi.  

Hacienda Puente Bagazo had been in the Zeno family ownership since 1812.  In 1841 Hacienda Puente Bagazo was owned by Infantry Capt. Manuel Antonio Zeno Carrión (1789-1842) and its administrator was Juan Watlington.  Upon Manuel Antonio's death in 1842, Hacienda Puente Bagazo was inherited by his son Manuel de Jesús Zeno Correa.  In 1845 Hacienda Puente Bagazo was the largest sugar plantation in Arecibo consisting of some 3,700 cuerdas.   

In 1878, the Zeno family lost Hacienda Puente Bagazo due to excessive debts to G. Ledesma & Cia. and Torres & Cia. and was acquired by Petra Berrios who leased it to Sebastian Figueroa Colón.  Shortly before this event, Manuel de Jesús and Maria de la Concepción decided to sell their part of Santa Barbara to avoid losing it the same way they eventually lost Puente Bagazo.  We don' know how Maria de la Concepción disposed of her part but it appears Amalia sold her part to Rafael Balseiro Maceira (1833-1902), father in law and partner of Eduardo Giorgetti in the mercantile firm Balsiro & Giorgetti.

The Gaceta de Puerto Rico in its edition of April 18, 1889, states that in March 1889, as the result of a court case established by Amalia Gandia de Ibañez against Rafael Balseiro Maceira, the district judge ordered to be sold at public auction three tracts of land consisting of 174 cuerdas and a sugarcane factory known as Hacienda Santa Bárbara, located in Barrio Cambalache.  The succesful bidders at public auction were Antonio and Miguel Roses Bisbal who paid 22,000 in the current currency.  In 1895 a right was granted Antonio Roses Bisbal to use 90 liters of water per second from the Rio Grande de Arecibo for irrigating 118 hectares of Hacienda Santa Bárbara.

Brothers Ramón (1824- ), Miguel (1838-1890) and Antonio (1842-1898) Roses Bisbal emigrated to Puerto Rico from Sóller, Mallorca in the 1850s and '60s.  The first to arrive was Ramón who was a sailor in a frigate that made regular voyages between Puerto Rico and Spain.  Miguel followed and had his first job at La Mallorquina Restaurant in San Juan.  He married Spanish immigrant from Gerona, Catalonia Elvira Artau Costa (1849- ), a resident of Utuado whose family owned the coffee plantation Hacienda Raimunda, coffee growers and exporters.  Miguel and Elvira relocated to Arecibo and in 1862 Miguel established Roses & Garcia together with Sebastian Garcia Puigserver.  In 1868, Antonio Roses Bisbal and Juan Rubert Catalá joined the business which from then on was known as Roses, Garcia & Cia.  In 1873 when Sebastian Garcia Puigserver retired, the business was renamed Roses, Rubert & Co. and in 1876 when Juan Rubert Catalá was no longer part of the firm, it was renamed Roses & Cia.

On or around 1868 Roses, Garcia & Cia. started distilling and marketing Ron de la Casa Roses from aguardiente they produced at Hacienda Anones which they had leased from José Maria Figueroa.  Further incursion in the rum business was made in 1882 when Pedro Antonio Pizá Bisbal (1853-1911) established the firm Pizá & Cia., makers of Ron Pizá, where Roses y Cía. figured as a limited partner.  Every year Roses & Cia. continued to improve their product until Ron Llave was brought to market in 1891 which was an instant hit.

 When Miguel Roses Bisbal died in 1890, his share in Roses & Cia.  was split between his brothers Antonio and Ramón.  Antonio received 100% of the agricultural/industrial side which included the then 360 acre Hacienda Santa Barbara.  Ramón received the commercial  side  which was reorganized into a new corporation named Roses & Co., Inc., owned and managed by his nephews Andrés (1876- ) and Lorenzo (1871- ) Oliver Roses who had arrived in Arecibo in 1885 and 1891 respectively.   Andres and Lorenzo were sons of Catalina Roses Bisbal and Andrés Oliver Mir.  In 1892 Antonio Roses Bisbal retired and returned to live in Barcelona, Roses & Cia. was then reorganized and renamed Sucrs. de Roses & Cia.  In that reorganization, Lorenzo Roses Borrás (son of Bartolomé Roses Bisbal) and Antonio Figueras Cerdá (1866-1933) became partners.

Sucrs. de Roses & Cia. leased Hacienda Santa Barbara from Antonio and installed a new still that allowed increased production of Ron Llave.  Sales were far better than expected to the extent that by 1893 Sucrs. de Roses & Cia. began exporting the product to Spain.  Ron Llave was distilled at Hacienda Santa Bárbara until 1901.  That year a larger capacity still was acquired and installed at Central Plazuelawhere Ron Llave was distilled until 1906.  By that year Central Cambalache had started operations so they acquired their own facilities in Barrio Miramar of Arecibo where they distilled Ron Llave from 1906 to 1911 using molasses from Central Cambalache. 

After distilling operations ceased at Hacienda Santa Barbara in 1901, the following year, while under the administration of Andrés Oliver Roses, Santa Barbara sugar factory ceased operations and sugarcane grown on its land was processed at Central Monte Grande.  In 1905, then operating under the name Sucrs. Roses & Cia., Santa Barbara was part of the lands that formed part of the new Central Cambalache, Inc. of which Sucrs. Roses & Cia. were important shareholders.

After their Hacienda Santa Barbara was incorporated into the newly organized Central Cambalache, Sucrs. Roses & Cia. continued their wholesale distribution and liquor business.  In 1911 Sucrs. de Roses & Cia. became part of the newly organized Puerto Rico Distilling Co., Inc.  Today, Ron Llave is still being distilled, now by Destileria Serrallés in Ponce.

Hacienda Santa Barbara was located about 1 mile traveling north on PR-2 from the remains of Central Cambalache.